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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SAMHD1
All Species:
31.82
Human Site:
S433
Identified Species:
58.33
UniProt:
Q9Y3Z3
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9Y3Z3
NP_056289.2
626
72201
S433
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
Chimpanzee
Pan troglodytes
XP_514624
382
43769
G203
I
L
C
V
Q
I
A
G
L
C
H
D
L
G
H
Rhesus Macaque
Macaca mulatta
XP_001097562
728
83194
S535
I
F
L
E
I
L
Y
S
T
D
P
K
L
K
D
Dog
Lupus familis
XP_542986
665
76981
S471
I
F
L
E
I
L
Y
S
S
D
P
N
L
N
E
Cat
Felis silvestris
Mouse
Mus musculus
Q60710
627
72632
S445
I
F
L
E
V
L
H
S
T
D
P
Q
L
S
E
Rat
Rattus norvegicus
XP_230789
677
77635
S495
I
F
L
E
I
L
Y
S
T
D
P
Q
L
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJL9
614
70202
S424
I
Y
L
E
I
L
H
S
S
R
P
E
L
S
E
Frog
Xenopus laevis
Q6INN8
632
72730
S438
I
Y
H
Q
I
L
Y
S
N
D
P
N
L
K
E
Zebra Danio
Brachydanio rerio
Q502K2
622
71649
S413
I
F
E
Q
I
L
Y
S
S
G
P
E
L
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09374
587
66474
S384
V
E
Q
E
I
L
N
S
Q
I
T
D
P
K
M
Sea Urchin
Strong. purpuratus
XP_784786
594
68895
H410
M
T
D
G
V
L
E
H
I
L
L
S
K
T
K
Poplar Tree
Populus trichocarpa
XP_002312899
477
54770
S298
N
D
Y
L
Q
I
S
S
F
I
E
D
P
S
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568580
473
54655
S294
A
N
N
H
L
E
I
S
S
M
I
N
D
P
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58.9
79.5
73.5
N.A.
73.3
65.8
N.A.
N.A.
60
61.8
60.8
N.A.
N.A.
N.A.
22.5
46.8
Protein Similarity:
100
60.2
82.4
83.6
N.A.
83.2
76.2
N.A.
N.A.
74.9
75.3
74.1
N.A.
N.A.
N.A.
40.8
64.2
P-Site Identity:
100
13.3
100
73.3
N.A.
66.6
80
N.A.
N.A.
53.3
60
53.3
N.A.
N.A.
N.A.
33.3
6.6
P-Site Similarity:
100
20
100
86.6
N.A.
93.3
93.3
N.A.
N.A.
86.6
80
80
N.A.
N.A.
N.A.
40
20
Percent
Protein Identity:
28.2
N.A.
N.A.
30.5
N.A.
N.A.
Protein Similarity:
45
N.A.
N.A.
47.2
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
8
8
0
0
0
0
0
0
47
0
24
8
0
16
% D
% Glu:
0
8
8
54
0
8
8
0
0
0
8
16
0
0
54
% E
% Phe:
0
47
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
8
0
8
0
0
0
8
0
% G
% His:
0
0
8
8
0
0
16
8
0
0
8
0
0
0
8
% H
% Ile:
70
0
0
0
62
16
8
0
8
16
8
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
16
8
31
8
% K
% Leu:
0
8
47
8
8
77
0
0
8
8
8
0
70
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% M
% Asn:
8
8
8
0
0
0
8
0
8
0
0
24
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
62
0
16
8
0
% P
% Gln:
0
0
8
16
16
0
0
0
8
0
0
16
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
8
85
31
0
0
8
0
39
8
% S
% Thr:
0
8
0
0
0
0
0
0
31
0
8
0
0
8
0
% T
% Val:
8
0
0
8
16
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
16
8
0
0
0
47
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _